Concepedia

Microbial hydrogen economy alleviates colitis by reprogramming colonocyte metabolism and reinforcing intestinal barrier

Li Ge, Jie Qi, Bo Shao, Zhenzhen Ruan, Yueran Ren, Shujing Sui, Xinpei Wu, Xueqiang Sun, Shuman Liu, Sha Li,

Gut Microbes · 2022 · 67 citations · 40 references

DOIFull text

Open access

Concepts

Abstract

-gut microbiota-SCFAs axis and strengthens the intestinal barrier by modulating specific mucosa-associated mucolytic bacteria, wherein improved microbial hydrogen economy alleviates colitis.

References

40

Structure, function and diversity of the healthy human microbiome

Curtis Huttenhower, J. Fah Sathirapongsasuti, Nicola Segata et al. · Nature · 2012 · 11.9K citations · Full text

, , +17

Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

Ikuroh Ohsawa, Masahiro Ishikawa, Kumiko Takahashi et al. · Nature Medicine · 2007 · 2.5K citations

, , +13

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

Malin Johansson, Mia Phillipson, Joel Petersson et al. · Proceedings of the National Academy of Sciences · 2008 · 2.2K citations · Full text

, , +16

Dextran Sulfate Sodium (DSS)‐Induced Colitis in Mice

Benoît Chassaing, J D Aitken, Madhu Malleshappa et al. · Current Protocols in Immunology · 2014 · 2.1K citations

, , +17

Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium

Muriel Derrien, Elaine E. Vaughan, Caroline M. Plugge et al. · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · 2004 · 2K citations · Full text

, , +10