Concepedia

A self-amplifying nanodrug to manipulate the Janus-faced nature of ferroptosis for tumor therapy

Mengzhu Zhang, Xiaohan Qin, Zhipeng Zhao, Qian Du, Qian Li, Yue Jiang, Yuxia Luan

Nanoscale Horizons · 2021 · 133 citations · 27 references

DOI

Concepts

Abstract

the genetic blockade effect. The RCH NPs thus demonstrated superior therapeutic effects on tumors, thanks to self-amplifying ferroptotic immunotherapy. Our work offers a conceptually innovative strategy for harnessing ferroptosis against tumors.

References

27

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Weimin Wang, Michael D. Green, Jae Eun Choi et al. · Nature · 2019 · 2.8K citations · Full text

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Up-Regulation of PD-L1, IDO, and T <sub>regs</sub> in the Melanoma Tumor Microenvironment Is Driven by CD8 <sup>+</sup> T Cells

Stefani Spranger, Robbert M. Spaapen, Yuanyuan Zha et al. · Science Translational Medicine · 2013 · 1.7K citations · Full text

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Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy

Qian Chen, Ligeng Xu, Chao Liang et al. · Nature Communications · 2016 · 1.6K citations · Full text

, , +17