GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity

SCANPY: large-scale single-cell gene expression data analysis

F. Alexander Wolf, Philipp Angerer, Fabian J. Theis · Genome biology · 2018 · 9.3K citations · Full text

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T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

Daniel W Lee, James N. Kochenderfer, Maryalice Stetler‐Stevenson et al. · The Lancet · 2014 · 2.9K citations

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Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy

Christine E. Brown, Darya Alizadeh, Renate Starr et al. · New England Journal of Medicine · 2016 · 1.8K citations · Full text

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4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

Adrienne H. Long, Waleed Haso, Jack F. Shern et al. · Nature Medicine · 2015 · 1.8K citations · Full text

Life Sciences, Immunology, Molecular Biology +17

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma

Donald M. O’Rourke, MacLean P. Nasrallah, Arati Desai et al. · Science Translational Medicine · 2017 · 1.8K citations · Full text

Medicine, Immunology, Oncology +17