Design and synthesis of marine sesterterpene analogues as novel estrogen receptor α degraders for breast cancer treatment

Estrogen Receptor Status by Immunohistochemistry Is Superior to the Ligand-Binding Assay for Predicting Response to Adjuvant Endocrine Therapy in Breast Cancer

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Small-molecule hydrophobic tagging–induced degradation of HaloTag fusion proteins

Taavi K. Neklesa, Hyun Seop Tae, Ashley R. Schneekloth et al. · Nature Chemical Biology · 2011 · 423 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +11

Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER)

Jiantao Hu, Biao Hu, Mingliang Wang et al. · Journal of Medicinal Chemistry · 2019 · 271 citations

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Measuring Residual Estrogen Receptor Availability during Fulvestrant Therapy in Patients with Metastatic Breast Cancer

Michel van Kruchten, Elisabeth G.E. de Vries, Andor W.J.M. Glaudemans et al. · Cancer Discovery · 2014 · 231 citations

Medicine, Nuclear Medicine, Oncology +17

Small‐Molecule‐Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging

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Medicine, Oncology, Pharmacology +17