Novel chemical inhibitor against SOD1 misfolding and aggregation protects neuron-loss and ameliorates disease symptoms in ALS mouse model

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

D.R. Rosen, Teepu Siddique, David T. Patterson et al. · Nature · 1993 · 7K citations

Neurodegenerative Diseases, Amyotrophic Lateral Sclerosis, Neurological Disorder +7

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

Mark E. Gurney, Haifeng Pu, Arlene Y. Chiu et al. · Science · 1994 · 4.1K citations

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

Jiayi Li, Elisabet Englund, Janice L. Holton et al. · Nature Medicine · 2008 · 1.8K citations

Host-to-graft Disease Propagation, Experimental Neuropathology, Lewy Bodies +7

Transmission and spreading of tauopathy in transgenic mouse brain

Florence Clavaguera, Tristan Bolmont, R. Anthony Crowther et al. · Nature Cell Biology · 2009 · 1.8K citations · Full text

Knockout Mouse, Neurodegenerative Diseases, Xenotransplantation +7

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

Jeffrey H. Kordower, Yaping Chu, Robert A. Hauser et al. · Nature Medicine · 2008 · 1.7K citations

Neurodegenerative Diseases, Parkinson Disease, Neuroscience +5