Autophagy · 2021 · 15 citations · 62 references
Life SciencesMolecular BiologyNeuroscienceAutophagyMolecular NeuroscienceNeurodegenerationAmyotrophic Lateral SclerosisMitophagyMolecular Basis Of NeurodegenerationNeurodegenerative DiseasesNeurodegenerative DisordersProtein Aggregation DisordersAmyotrophic Lateral Sclerosis AutophagyAmyotrophic Lateral Sclerosis PathologyMacroautophagy RegulationNeurodegeneration PathogenesisNeurodegenerative Disease MechanismsNeurodegenerative Pathway MechanismsTar Dna-binding Protein 43 PathologyTardbp Mutations
transcript. Overexpression of SQSTM1 could diminish the cytoplasmic C-terminal TARDBP accumulation in the monkey brain by augmenting macroautophagy/autophagy activity. Our findings provide additional clues for the pathogenesis of cytoplasmic TARDBP and a potential therapy for mutant TARDBP-mediated neuropathology.
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Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
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Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice
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TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
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Life Sciences, Genetics, Neurology +14
Characterizing the RNA targets and position-dependent splicing regulation by TDP-43
James Tollervey, Tomaž Curk, Boris Rogelj et al. · Nature Neuroscience · 2011 · 1.2K citations · Full text