Multiple forms of human P450 expressed in Saccharomyces cerevisiae

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

Tsutomu Shimada, Hiroshi Yamazaki, Mayumi Mimura et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 2.8K citations

Medicine, Biochemistry, Pharmacology +15

Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.

F. Peter Guengerich, M V Martin, Philippe Beaune et al. · Journal of Biological Chemistry · 1986 · 730 citations · Full text

Medicine, Biochemistry, Pharmacology +17

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

Frank J. Gonzalez, Radek C. Skodat, Shioko Kimura et al. · Nature · 1988 · 718 citations

Life Sciences, Genetics, Molecular Genetics +12

Separation and characterization of highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, and 3-methylcholanthrene.

Dene E. Ryan, Daria Korzeniowski, Wayne Levin · Journal of Biological Chemistry · 1979 · 576 citations · Full text

Medicine, Biochemistry, Toxicology +17

Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme.

Byoung‐Joon Song, Harry V. Gelboin, S S Park et al. · Journal of Biological Chemistry · 1986 · 409 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13