The relationship between enkephalin degradation and opiate receptor occupancy.

Identification of two related pentapeptides from the brain with potent opiate agonist activity

Joel W. Hughes, Terry Smith, H. W. Kosterlitz et al. · Nature · 1975 · 3.8K citations

Neurophysiology, Neuroanatomy, Related Pentapeptides +11

Structural chemistry and molecular biology

Alexander Rich, Norman Davidson, Linus Pauling · Medical Entomology and Zoology · 1968 · 1.7K citations

Structure Determination, Structure Elucidation, Structural Biology +1

Opiates and endogenous opioid peptides

John Kelly, Raymond Dingledine · Trends in Biochemical Sciences · 1977 · 1.3K citations

Addiction, Medicine, Neuropharmacology +5

Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine

John Hughes · Brain Research · 1975 · 980 citations

Molecular Pharmacology, Psychoactive Drug, Pharmacological Study +13

Analgesia induced in vivo by central administration of enkephalin in rat

James D. Belluzzi, Norman H. Grant, Victor M. Garsky et al. · Nature · 1976 · 528 citations

Central Administration, Health Sciences, Pain Medicine +13