Analgesia induced in vivo by central administration of enkephalin in rat

Identification of two related pentapeptides from the brain with potent opiate agonist activity

Joel W. Hughes, Terry Smith, H. W. Kosterlitz et al. · Nature · 1975 · 3.8K citations

Medicine, Medicinal Chemistry, Pharmacology +13

A METHOD FOR DETERMINING LOSS OF PAIN SENSATION

F. E. D'Amour, Donn L. Smith · Journal of Pharmacology and Experimental Therapeutics · 1941 · 3.2K citations

Nursing, Pharmacology, Pain Management +14

Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine

John Hughes · Brain Research · 1975 · 981 citations

Medicine, Neuroscience, Pharmacology +14

Regional Distribution of Opiate Receptor Binding in Monkey and Human Brain

Michael J. Kuhar, Candace B. Pert, Solomon H. Snyder · Nature · 1973 · 818 citations

Medicine, Neurobiology, Neuroscience +9

Analgesia from Electrical Stimulation in the Brainstem of the Rat

David J. Mayer, Thomas L. Wolfle, Huda Akil et al. · Science · 1971 · 763 citations

Life Sciences, Neurobiology, Neuroscience +16