Concepedia

Sphingosine‐1‐phosphate promotes tumor development and liver fibrosis in mouse model of congestive hepatopathy

Hironari Kawai, Yosuke Osawa, Michitaka Matsuda, Tomoyuki Tsunoda, K. Yanagida, Daisuke Hishikawa, Miku Okawara, Yuzuru Sakamoto, Tomonari Shimagaki, Yuriko Tsutsui,

Hepatology · 2021 · 70 citations · 28 references

DOI

Abstract

In conclusion, chronic liver congestion promotes HCC development and liver fibrosis by S1P production from LPS-induced capillarized LSECs. Careful treatment of both RHF and liver cancer might be necessary for patients with RHF with primary or metastatic liver cancer.

References

28

TLR4 enhances TGF-β signaling and hepatic fibrosis

Ekihiro Seki, Samuele De Minicis, Christoph H. Österreicher et al. · Nature Medicine · 2007 · 1.9K citations

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Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4

Dianne H. Dapito, Ali Mencin, Geum‐Youn Gwak et al. · Cancer Cell · 2012 · 1.3K citations · Full text

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

Jie Liang, Masayuki Nagahashi, Eugene Y. Kim et al. · Cancer Cell · 2012 · 550 citations · Full text

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Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

Nobuhiro Nakamoto, Nobuo Sasaki, Ryo Aoki et al. · Nature Microbiology · 2019 · 400 citations

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Role of Differentiation of Liver Sinusoidal Endothelial Cells in Progression and Regression of Hepatic Fibrosis in Rats

Guanhua Xie, Xiangdong Wang, Lei Wang et al. · Gastroenterology · 2011 · 398 citations · Full text

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