Two microbiota subtypes identified in irritable bowel syndrome with distinct responses to the low FODMAP diet

Abstract

50% of IBS cases manifested a 'pathogenic' gut microbial signature. This shifted towards the healthy profile on the low FODMAP diet; and IBS^P cases showed an enhanced clinical responsiveness to the dietary therapy. The effectiveness of FODMAP reduction in IBS^P may result from the alterations in gut microbiota and metabolites produced. Microbiota signatures could be useful as biomarkers to guide IBS treatment; and investigating IBS^P species and metabolic pathways might yield insights regarding IBS pathogenic mechanisms.