Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets

Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).

Owen W. Griffith, A Meister · Journal of Biological Chemistry · 1979 · 1.7K citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Specific Inhibition +13

Web-based inference of biological patterns, functions and pathways from metabolomic data using MetaboAnalyst

Jianguo Xia, David S. Wishart · Nature Protocols · 2011 · 1.3K citations

Metabolic Network, Systems Biology, Engineering +13

Real-time imaging of the intracellular glutathione redox potential

Marcus Gutscher, Anne‐Laure Pauleau, Laurent Marty et al. · Nature Methods · 2008 · 900 citations

Tissue Imaging, Engineering, Biochemistry +8

Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis.

Owen W. Griffith · Journal of Biological Chemistry · 1982 · 700 citations · Full text

Gsh Equivalents, Pharmacotherapy, Pharmaceutical Chemistry +19

MetaboAnalystR 3.0: Toward an Optimized Workflow for Global Metabolomics

Zhiqiang Pang, Jasmine Chong, Shuzhao Li et al. · Metabolites · 2020 · 555 citations · Full text