A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat

Lawrence Kazak, Edward T. Chouchani, Mark P. Jedrychowski, +10

Cell

NutritionEnergy HomeostasisEnergy MetabolismBody CompositionBiochemistry +9

A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging

Haopeng Xiao, Mark P. Jedrychowski, Devin K. Schweppe, +17

Cell

Reductive StressAgingRedox RegulatorLongevityMedicine +8

Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity

Lawrence Kazak, Edward T. Chouchani, Gina Z. Lu, +11

Cell Metabolism

ObesityNutritionMetabolic SyndromeSystems BiologyDrives Obesity +10

pH-Gated Succinate Secretion Regulates Muscle Remodeling in Response to Exercise

Anita Reddy, Luiz H. M. Bozi, Omar Yaghi, +17

Cell

Muscle FunctionCellular PhysiologyMuscle PhysiologyPhysiological ResearchKinesiology +14

Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses

P. Kent Langston, Aya Nambu, Jonathan Jung, +13

Nature Immunology

InflammationMacrophage Inflammatory ResponsesSignal TransductionCell SignalingImmunology +7

Lactate regulates cell cycle by remodelling the anaphase promoting complex

Weihai Liu, Yun Wang, Luiz H. M. Bozi, +25

Nature

Anaphase Promoting ComplexSignal TransductionDevelopmental BiologyCell DivisionCell Regulation +8

Microglial metabolism is a pivotal factor in sexual dimorphism in Alzheimer’s disease

Marie‐Victoire Guillot‐Sestier, Ana Rubio Araiz, Virginia Mela, +6

Communications Biology

Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity

Lawrence Kazak, Janane F. Rahbani, Bożena Samborska, +13

Nature Metabolism

ObesityMetabolic SyndromeEnergy HomeostasisEnergy MetabolismPhysiology +6

Mitochondrial uncouplers induce proton leak by activating AAC and UCP1

Ambre M. Bertholet, Andrew M. Natale, Paola Bisignano, +10

Nature

Mitochondrial UncouplersBiochemistryMitochondrial FunctionNatural SciencesMitochondrial Biogenesis +5

Sample multiplexing for targeted pathway proteomics in aging mice

Qing Yu, Haopeng Xiao, Mark P. Jedrychowski, +6

Proceedings of the National Academy of Sciences

BioinformaticsProteomic TechnologyDeep FractionationPathway ProteomicsMedicine +12