Concepedia

Ivacaftor restores delayed mucociliary transport caused by <i>Pseudomonas aeruginosa–</i>induced acquired cystic fibrosis transmembrane conductance regulator dysfunction in rabbit nasal epithelia

Do‐Yeon Cho, Shaoyan Zhang, Daniel Skinner, Dong Jin Lim, Catherine Banks, Jessica W. Grayson, Guillermo J. Tearney, Steven M. Rowe, Bradford A. Woodworth

International Forum of Allergy & Rhinology · 2021 · 16 citations · 40 references

DOIFull text

Open access

Abstract

In rabbit nasal epithelium, ivacaftor robustly stimulates CFTR-mediated Cl<sup>-</sup> secretion and normalizes ASL and CBF in PAO1-induced acquired CFTR dysfunction. Preclinical testing of CFTR potentiators as therapy for P aeruginosa rabbit sinusitis is planned.

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