Concepedia

Ectopic expression of <i>Irx3</i> and <i>Irx5</i> in the paraventricular nucleus of the hypothalamus contributes to defects in <i>Sim1</i> haploinsufficiency

Joe Eun Son, Zhengchao Dou, Siyi Wanggou, Jade Chan, Rong Mo, Xuejun Li, Xi Huang, Kyoung-Han Kim, Jacques L. Michaud, Chi‐chung Hui

Science Advances · 2021 · 12 citations · 49 references

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Concepts

Abstract

Irx3 and Irx5 misexpression in paraventricular nucleus of the hypothalamus leads to hyperphagic obesity in Sim1 haploinsufficiency.

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