Obesity-associated variants within FTO form long-range functional connections with IRX3

Scott Smemo, Juan J. Tena, Kyoung-Han Kim, +22

Nature

ObesityMetabolic SyndromeEnergy HomeostasisSignal TransductionMolecular Physiology +10

Adipose Vascular Endothelial Growth Factor Regulates Metabolic Homeostasis through Angiogenesis

Hoon‐Ki Sung, Kyung-Oh Doh, Joe Eun Son, +11

Cell Metabolism

ObesityMetabolic SyndromeAngiogenesisVascular AdaptationPhysiology +11

Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage

Kyoung-Han Kim, Yun Hye Kim, Joe Eun Son, +17

Cell Research

Isorhamnetin Suppresses Skin Cancer through Direct Inhibition of MEK1 and PI3-K

Jong‐Eun Kim, Dong Eun Lee, Ki Won Lee, +9

Cancer Prevention Research

Chemoprevention StrategyCell DeathDirect InhibitionCox-2 ExpressionDermatology +14

Methionine deprivation suppresses triple-negative breast cancer metastasis<i>in vitro</i>and<i>in vivo</i>

Hyein Jeon, Jae Hwan Kim, Eunjung Lee, +8

Oncotarget

Phosphoinositide 3-kinase is a novel target of piceatannol for inhibiting PDGF-BB-induced proliferation and migration in human aortic smooth muscle cells

Keun Hwa Choi, Jong‐Eun Kim, Nu Ry Song, +6

Cardiovascular Research

Cyanidin suppresses ultraviolet B-induced COX-2 expression in epidermal cells by targeting MKK4, MEK1, and Raf-1

Jong‐Eun Kim, Jung Yeon Kwon, Sang Kwon Seo, +7

Biochemical Pharmacology

Cancer ResearchCell RegulationReceptor Tyrosine KinaseEpidermal CellsTumor Suppressor +5

Cocoa polyphenols suppress TNF-α-induced vascular endothelial growth factor expression by inhibiting phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase kinase-1 (MEK1) activities in mouse epidermal cells

Jong‐Eun Kim, Joe Eun Son, Sung Keun Jung, +4

British Journal Of Nutrition

Immune RegulationImmunologyMouse Epidermal CellsDermatologyPolyphenolics +19

Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma

Wen-Chi Yin, Thevagi Satkunendran, Rong Mo, +20

Developmental Cell

Functional GenomicsSignal TransductionDual Regulatory FunctionsGeneticsGene Regulation +7

Licochalcone A, a Polyphenol Present in Licorice, Suppresses UV-Induced COX-2 Expression by Targeting PI3K, MEK1, and B-Raf

Nu Ry Song, Jong‐Eun Kim, Jun Eun Park, +8

International Journal of Molecular Sciences

Chalcone FamilyChemoprevention StrategyLipid PeroxidationUv-induced Cox-2 ExpressionLicorice Root +16