Concepedia

Lack of CD8 <sup>+</sup> T cell effector differentiation during priming mediates checkpoint blockade resistance in non–small cell lung cancer

Brendan Horton, Duncan M. Morgan, Noor Momin, Maria Zagorulya, Elen Torres-Mejia, Vidit Bhandarkar, K. Dane Wittrup, J. Christopher Love, Stefani Spranger

Science Immunology · 2021 · 129 citations · 83 references

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Abstract

A lung cancer–specific form of CD8 + T cell dysfunction is established during T cell priming and contributes to ICB resistance.

References

83

Fiji: an open-source platform for biological-image analysis

Johannes Schindelin, Ignacio Arganda‐Carreras, Erwin Frise et al. · Nature Methods · 2012 · 70.9K citations

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Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

Aravind Subramanian, Pablo Tamayo, Vamsi K. Mootha et al. · Proceedings of the National Academy of Sciences · 2005 · 56.7K citations · Full text

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Comprehensive Integration of Single-Cell Data

Tim Stuart, Andrew Butler, Paul Hoffman et al. · Cell · 2019 · 16.9K citations · Full text

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Integrating single-cell transcriptomic data across different conditions, technologies, and species

Andrew Butler, Paul Hoffman, Peter Smibert et al. · Nature Biotechnology · 2018 · 14.7K citations · Full text

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Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

Suzanne L. Topalian, F. Stephen Hodi, Julie R. Brahmer et al. · New England Journal of Medicine · 2012 · 12.7K citations · Full text

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