Concepedia

Delivery of gefitinib in synergism with thymoquinone <i>via</i> transferrin-conjugated nanoparticle sensitizes gefitinib-resistant non-small cell lung carcinoma to control metastasis and stemness

Priyanka Upadhyay, Avijit Ghosh, Arijita Basu, P. A. Pranati, P. C. Sen Gupta, Shaswati Das, Sushmita Sarker, Mousumi Bhattacharjee, Saurav Bhattacharya, Swatilekha Ghosh,

Biomaterials Science · 2021 · 16 citations · 39 references

DOI

Concepts

Abstract

The NP-Dual-3 causes the pH-dependent release of gefitinib and thymoquinone, which breaks the shield of the CSC niches, reduce cell migration and stemness in A549/GR cells by degradation of HIF1-α and downregulation of miR-21.

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