Inhibition of the NLRP3 inflammasome with MCC950 prevents chronic social isolation-induced depression-like behavior in male mice

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Rebecca C. Coll, Avril A. B. Robertson, Jae Jin Chae et al. · Nature Medicine · 2015 · 2.7K citations · Full text

Inflammation, Anti-inflammatory, Autoimmune Disease +14

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

Annett Halle, Veit Hornung, Gabor C. Petzold et al. · Nature Immunology · 2008 · 2.4K citations · Full text

Inflammation, Nalp3 Inflammasome, Innate Immune System +7

Perceived social isolation makes me sad: 5-year cross-lagged analyses of loneliness and depressive symptomatology in the Chicago Health, Aging, and Social Relations Study.

John T. Cacioppo, Louise C. Hawkley, Ronald A. Thisted · Psychology and Aging · 2010 · 1.7K citations

Social Isolation, Loneliness, Mental Health +19

Cognitive Recovery in Socially Deprived Young Children: The Bucharest Early Intervention Project

Charles A. Nelson, Charles H. Zeanah, Nathan A. Fox et al. · Science · 2007 · 941 citations

Disability, Education, Early Childhood Education +19

A Critical Period for Social Experience–Dependent Oligodendrocyte Maturation and Myelination

Manabu Makinodan, Kenneth M. Rosen, Susumu Ito et al. · Science · 2012 · 914 citations