Concepedia

TNF-α-dependent neuronal necroptosis regulated in Alzheimer's disease by coordination of RIPK1-p62 complex with autophagic UVRAG

Chong Xu, Jialin Wu, Yiqun Wu, Zhichu Ren, Yuyuan Yao, Guobing Chen, Evandro Fei Fang, Ji Heon Noh, Yong Liu, Libin Wei,

Theranostics · 2021 · 145 citations · 43 references

DOIFull text

Open access

Concepts

Abstract

We identify a finely controlled regulation of neuronal necroptosis in AD by coordinated TNF-α signaling, RIPK1/3 activity and autophagy machinery. Strategies that could fine-tune necroptosis and autophagy may bring in promising therapeutics for AD.

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