Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's disease

Yijiao Xu, Chunxiao Liu, Sujuan Chen, +9

Cellular Signalling

Mtor-mediated S6k1Signal TransductionApoptosisAutophagyCell Death +10

TNF-α-dependent neuronal necroptosis regulated in Alzheimer's disease by coordination of RIPK1-p62 complex with autophagic UVRAG

Chong Xu, Jialin Wu, Yiqun Wu, +9

Theranostics

<scp>N</scp>‐acetyl‐<scp>L</scp>‐cysteine protects against cadmium‐induced neuronal apoptosis by inhibiting<scp>ROS</scp>‐dependent activation of<scp>A</scp>kt/m<scp>TOR</scp>pathway in mouse brain

Sujuan Chen, Qian Ren, Jinfei Zhang, +10

Neuropathology and Applied Neurobiology

Rotenone Induction of Hydrogen Peroxide Inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E Pathways, Leading to Neuronal Apoptosis

Qian Zhou, Chunxiao Liu, Wen Liu, +8

Toxicological Sciences

Rapamycin ameliorates cadmium-induced activation of MAPK pathway and neuronal apoptosis by preventing mitochondrial ROS inactivation of PP2A

Chong Xu, Xiaoxue Wang, Yu Zhu, +6

Neuropharmacology

MitophagyMitochondrial Ros InactivationMolecular NeuroscienceSignal TransductionMitochondrial Function +9

Cadmium results in accumulation of autophagosomes-dependent apoptosis through activating Akt-impaired autophagic flux in neuronal cells

Hai Zhang, Xiaoqing Dong, Rui Zhao, +7

Cellular Signalling

Cell AutophagyMitophagyApoptosisAutophagyPhysiology +11

Rapamycin inhibits BAFF-stimulated cell proliferation and survival by suppressing mTOR-mediated PP2A-Erk1/2 signaling pathway in normal and neoplastic B-lymphoid cells

Qingyu Zeng, Hai Zhang, Jiamin Qin, +9

Cellular and Molecular Life Sciences

Cancer ResearchSignaling PathwayNeoplastic B-lymphoid CellsCell RegulationMedicine +8

Celastrol prevents cadmium‐induced neuronal cell death by blocking reactive oxygen species‐mediated mammalian target of rapamycin pathway

Ruijie Zhang, Nana Zhang, Hai Zhang, +9

British Journal of Pharmacology

Celastrol prevents cadmium‐induced neuronal cell death via targeting JNK and PTEN‐Akt/<scp>mTOR</scp> network

Sujuan Chen, Chenjian Gu, Chong Xu, +6

Journal of Neurochemistry

Effects of Platycodin D on Proliferation, Apoptosis and PI3K/Akt Signal Pathway of Human Glioma U251 Cells

Chong Xu, Guibo Sun, Guangxin Yuan, +2

Molecules

ApoptosisCell DeathHigh-grade GliomasGliomaTumor Biology +15