RIP2 knockdown inhibits cartilage degradation and oxidative stress in IL-1β-treated chondrocytes via regulating TRAF3 and inhibiting p38 MAPK pathway

Efficacy, pharmacodynamics, and safety of VX‐702, a novel p38 MAPK inhibitor, in rheumatoid arthritis: Results of two randomized, double‐blind, placebo‐controlled clinical studies

Nemanja Damjanov, Robert S. Kauffman, G Spencer-Green · Arthritis & Rheumatism · 2009 · 246 citations

Medicine, Pharmacology, Pharmacotherapy +10

NF-κB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism

Zhenqiang Yao, Lianping Xing, Brendan F. Boyce · Journal of Clinical Investigation · 2009 · 150 citations · Full text

Veterinary Medicine, Immunology, Bone Metabolism +9

Signaling via the RIP2 Adaptor Protein in Central Nervous System-Infiltrating Dendritic Cells Promotes Inflammation and Autoimmunity

Patrick J. Shaw, Maggie Barr, John R. Lukens et al. · Immunity · 2011 · 150 citations · Full text

Life Sciences, Immunology, Neuroscience +12

The Identification and Pharmacological Characterization of 6-( <i>tert</i> -Butylsulfonyl)- <i>N</i> -(5-fluoro-1 <i>H</i> -indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase

Pamela A. Haile, Bartholomew J. Votta, Robert W. Marquis et al. · Journal of Medicinal Chemistry · 2016 · 124 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling

Tatiana Goncharov, Stefanie Hedayati, Melinda M. Mulvihill et al. · Molecular Cell · 2018 · 120 citations · Full text

Life Sciences, Immunology, Molecular Biology +10