Pharmacological characterization of GLPG1972/S201086, a potent and selective small-molecule inhibitor of ADAMTS5 - Concepedia

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Publication | Open Access

Pharmacological characterization of GLPG1972/S201086, a potent and selective small-molecule inhibitor of ADAMTS5

DOI Full Paper Access

25

Citations

39

References

2021

Year

P. Clément-Lacroix, Christopher B. Little, Margaret M. Smith, C. Cottereaux, Didier Merciris, S. Meurisse, Patrick Mollat, Robert Touitou, F. Brebion, Romain Gosmini,

Osteoarthritis and Cartilage

Abstract

GLPG1972/S201086 is a potent, selective and orally available ADAMTS5 inhibitor, demonstrating significant protective efficacy on both cartilage and subchondral bone in two relevant in vivo preclinical OA models.

References

	Year	Citations

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