Yearbook of pediatric endocrinology · 2021 · 13 citations · 0 references
Life SciencesGeneticsMolecular GeneticsEpigeneticsEpigenomicsGenomicsDiabetes MellitusDisease Susceptibility LociEpigenomic Data AnalysisGenome-wide Association StudiesSingle-cell EpigenomicsSingle-cell GenomicsChromatin Dna ArchitectureDisease-specific Susceptibility LociDna Methylation PatternsExocrine OrgansGenome-wide Association InterpretationSingle-cell Epigenomic ProfilingType 1 Diabetes AssociationsType 1 Diabetes Epidemiology
The authors report a large genome-wide association study (GWAS) of type 1 diabetes (T1D) in 18 942 cases and 501 638 controls, finding 92 T1D-associated genomic loci (59 known and 33 novel). Furthermore they analyse DNA chromatin patterns in pancreas and peripheral white blood cells to help identify the underlying genes. T1D-associated loci were linked to genes that are active in T cells, but also in the acinar and ductal cells of the exocrine pancreas.