Interpreting type 1 diabetes risk with genetics and single-cell epigenomics

Joshua Chiou, Ryan J. Geusz, Mei-Lin Okino, +12

Nature

Genome-wide Association StudyMetabolic SyndromeType 1Genetic DeterminantDiabetes Epidemiology +8

An atlas of dynamic chromatin landscapes in mouse fetal development

David U. Gorkin, Iros Barozzi, Yuan Zhao, +39

Nature

An atlas of gene regulatory elements in adult mouse cerebrum

Yang Eric Li, Xiaomeng Hou, Ziyang Zhang, +24

Nature

Single-cell chromatin accessibility identifies pancreatic islet cell type– and state-specific regulatory programs of diabetes risk

Joshua Chiou, Chun Zeng, Cheng Zhang, +16

Nature Genetics

ChromatinChromatin StructureNatural SciencesGeneticsDiabetes +8

Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk

William W. Greenwald, Joshua Chiou, Jian Yan, +19

Nature Communications

Genomic alterations in<i>BCL2L1</i>and<i>DLC1</i>contribute to drug sensitivity in gastric cancer

Hansoo Park, Sung‐Yup Cho, Hyerim Kim, +18

Proceedings of the National Academy of Sciences

High prevalence of TP53 mutations is associated with poor survival and an EMT signature in gliosarcoma patients

Sung‐Yup Cho, Chang‐Ho Park, Deukchae Na, +21

Experimental & Molecular Medicine

Methionine sulfoxide reductase B in the endoplasmic reticulum is critical for stress resistance and aging in Drosophila

Do‐Hwan Lim, Jee Yun Han, Jae-Ryong Kim, +2

Biochemical and Biophysical Research Communications

Lifespan ExtensionReductive StressDevelopmental BiologyStress ResistanceNatural Sciences +10

Mapping genetic effects on cell type-specific chromatin accessibility and annotating complex immune trait variants using single nucleus ATAC-seq in peripheral blood

Paola Benaglio, Jacklyn Newsome, Jee Yun Han, +8

PLoS Genetics

GeneticsChromatin Accessibility QtlsImmunologyPeripheral BloodGenomics +21

Ecdysone‐responsive microRNA‐252‐5p controls the cell cycle by targeting Abi in <i>Drosophila</i>

Do‐Hwan Lim, Seungjae Lee, Jee Yun Han, +5

The FASEB Journal