CRISPR/Cas12a-regulated homogeneous electrochemical aptasensor for amplified detection of protein

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

Janice S. Chen, Enbo Ma, Lucas B. Harrington et al. · Science · 2018 · 4.4K citations

Life Sciences, Genetics, Molecular Biology +13

A Green Approach to the Synthesis of Graphene Nanosheets

Hui-Lin Guo, Xianfei Wang, Qingyun Qian et al. · ACS Nano · 2009 · 2.3K citations

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Exploring the Trans‐Cleavage Activity of CRISPR‐Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor

Yifan Dai, Rodrigo A. Somoza, Liu Wang et al. · Angewandte Chemie International Edition · 2019 · 645 citations · Full text

Engineering, Biotechnology, Molecular Biology +17

Structural Basis for Guide RNA Processing and Seed-Dependent DNA Targeting by CRISPR-Cas12a

Daan C. Swarts, John van der Oost, Martin Jínek · Molecular Cell · 2017 · 642 citations · Full text

Life Sciences, Genetics, Molecular Biology +14

Integrating CRISPR-Cas12a with a DNA circuit as a generic sensing platform for amplified detection of microRNA

Shuang Peng, Zhen Tan, Siyu Chen et al. · Chemical Science · 2020 · 273 citations · Full text

Engineering, Biotechnology, Molecular Biology +14