Nature Communications · 2021 · 111 citations · 31 references
EngineeringBiological EngineeringBiotechnologyMetabolic EngineeringMicrobial MetabolismSynthetic BiologyCell Factory DesignMetabolic Pathway EngineeringMicrobial Cell FactoriesMicrobial Metabolic EngineeringMicrobial Synthetic BiologySynthetic Pathway ConstructionGrowth-coupled SelectionMetabolic Pathway OptimizationMicrobial Cell Factory DesignModular Evolution Of Metabolic NetworksOptimization Of Heterologous PathwaysPathway ModularizationSynthetic Gene Circuit DesignSynthetic Metabolic Pathways
Synthetic biology has brought about a conceptual shift in our ability to redesign microbial metabolic networks. Combining metabolic pathway-modularization with growth-coupled selection schemes is a powerful tool that enables deep rewiring of the cell factories’ biochemistry for rational bioproduction.
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