Concepedia

Design, synthesis, and biological evaluation of 1-methyl-1H-pyrazolo[4,3-b]pyridine derivatives as novel small-molecule inhibitors targeting the PD-1/PD-L1 interaction

Xinyan Dai, Ke Wang, Hao Chen, Xupeng Huang, Zhiqiang Feng

Bioorganic Chemistry · 2021 · 26 citations · 13 references

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References

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PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

Loise M. Francisco, Victor H. Salinas, Keturah Brown et al. · The Journal of Experimental Medicine · 2009 · 2K citations · Full text

Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1

Katarzyna Guzik, Krzysztof M. Żak, P. Grudnik et al. · Journal of Medicinal Chemistry · 2017 · 352 citations · Full text

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CA-170 – A Potent Small-Molecule PD-L1 Inhibitor or Not?

Bogdan Musielak, Justyna Kocik-Krol, Łukasz Skalniak et al. · Molecules · 2019 · 148 citations · Full text

Design, Synthesis, Evaluation, and Structural Studies of <i>C</i><sub>2</sub>-Symmetric Small Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein–Protein Interaction

Subhadwip Basu, Jeffrey Yang, Bin Xu et al. · Journal of Medicinal Chemistry · 2019 · 99 citations · Full text

Discovery of [1,2,4]Triazolo[4,3-<i>a</i>]pyridines as Potent Inhibitors Targeting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction

Mingze Qin, Qi Cao, Shuaishuai Zheng et al. · Journal of Medicinal Chemistry · 2019 · 90 citations · Full text