Discovery of phenyl-linked symmetric small molecules as inhibitors of the programmed cell death-1/programmed cell death-ligand 1 interaction

Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1)

Krzysztof M. Żak, P. Grudnik, Katarzyna Guzik et al. · Oncotarget · 2016 · 423 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +17

Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1

Katarzyna Guzik, Krzysztof M. Żak, P. Grudnik et al. · Journal of Medicinal Chemistry · 2017 · 360 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells

Łukasz Skalniak, Krzysztof M. Żak, Katarzyna Guzik et al. · Oncotarget · 2017 · 311 citations · Full text

Life Sciences, Immunology, Pharmacology +16

The IFN-γ/PD-L1 axis between T cells and tumor microenvironment: hints for glioma anti-PD-1/PD-L1 therapy

Jiawen Qian, Chen Wang, Bo Wang et al. · Journal of Neuroinflammation · 2018 · 264 citations · Full text

Medicine, Immunology, Oncology +17

Blockade of the PD-1/PD-L1 axis augments lysis of AML cells by the CD33/CD3 BiTE antibody construct AMG 330: reversing a T-cell-induced immune escape mechanism

Christina Krupka, Peter Kufer, Roman Kischel et al. · Leukemia · 2015 · 249 citations

Life Sciences, Immunology, Oncology +16