Roman Kischel

Blockade of the PD-1/PD-L1 axis augments lysis of AML cells by the CD33/CD3 BiTE antibody construct AMG 330: reversing a T-cell-induced immune escape mechanism

Christina Krupka, Peter Kufer, Roman Kischel et al. · Leukemia · 2015 · 239 citations

Autoimmune Disease, Immunology, Immunologic Mechanism +8

T-cell exhaustion induced by continuous bispecific molecule exposure is ameliorated by treatment-free intervals

Nora Philipp, Maryam Kazerani, Alyssa Nicholls et al. · Blood · 2022 · 215 citations · Full text

T-regulatory Cell, Immunology, Immunologic Mechanism +23

CD33 target validation and sustained depletion of AML blasts in long-term cultures by the bispecific T-cell–engaging antibody AMG 330

Christina Krupka, Peter Kufer, Roman Kischel et al. · Blood · 2013 · 199 citations

Cellular determinants for preclinical activity of a novel CD33/CD3 bispecific T-cell engager (BiTE) antibody, AMG 330, against human AML

George S. Laszlo, Chelsea J. Gudgeon, Kimberly H. Harrington et al. · Blood · 2013 · 170 citations · Full text

T cell-engaging BiTE antibodies specific for EGFR potently eliminate KRAS- and BRAF-mutated colorectal cancer cells

Ralf Lutterbuese, Tobias Raum, Roman Kischel et al. · Proceedings of the National Academy of Sciences · 2010 · 160 citations · Full text

Braf-mutated Crc Lines, Cancer Immunosurveillance, Low Doses Growth +11