Yizhe Wu

Structural Feature Analyzation Strategies toward Discovery of Orally Bioavailable PROTACs of Bruton’s Tyrosine Kinase for the Treatment of Lymphoma

Jingyu Zhang, Jinxin Che, Xiaomin Luo et al. · Journal of Medicinal Chemistry · 2022 · 50 citations · Full text

Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design

Xiaowu Dong, Wenhu Zhan, Mengting Zhao et al. · Journal of Medicinal Chemistry · 2019 · 27 citations · Full text

Discovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors

Wenhu Zhan, Jinxin Che, Lei Xu et al. · European Journal of Medicinal Chemistry · 2019 · 25 citations · Full text

Medicinal Chemistry, Active Akt Inhibitors, Medicine +10

Structure-based rational design enables efficient discovery of a new selective and potent AKT PROTAC degrader

Cheng‐Liang Zhu, Xiaomin Luo, Tian Tian et al. · European Journal of Medicinal Chemistry · 2022 · 25 citations

Combinatorial Chemistry, Medicinal Chemistry, Pharmaceutical Chemistry +13

Discovery of phenyl-linked symmetric small molecules as inhibitors of the programmed cell death-1/programmed cell death-ligand 1 interaction

Yizhe Wu, Yu Zhang, Yu Guo et al. · European Journal of Medicinal Chemistry · 2021 · 24 citations · Full text

Medicinal Chemistry, Natural Sciences, Apoptosis +9