Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance

Laura A. Kirkman, Wenhu Zhan, Joseph E. Visone, +31

Proceedings of the National Academy of Sciences

Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes

Ruda de Luna Almeida Santos, Lin Bai, Pradeep K. Singh, +11

Nature Communications

Integrating docking scores, interaction profiles and molecular descriptors to improve the accuracy of molecular docking: Toward the discovery of novel Akt1 inhibitors

Wenhu Zhan, Da-Qiang Li, Jinxin Che, +5

European Journal of Medicinal Chemistry

Medicinal ChemistryDrug TargetEngineeringMedicinePharmacology +9

Environmentally Ultrasensitive Fluorine Probe to Resolve Protein Conformational Ensembles by ¹⁹F NMR and Cryo-EM

Yun Huang, Krishna D. Reddy, Clay Bracken, +4

Journal of the American Chemical Society

Development of a Highly Selective <i>Plasmodium falciparum</i> Proteasome Inhibitor with Anti‐malaria Activity in Humanized Mice

Wenhu Zhan, Hao Zhang, John D. Ginn, +23

Angewandte Chemie International Edition

Structure of the human UBR5 E3 ubiquitin ligase

Feng Wang, Qing He, Wenhu Zhan, +5

Structure

Protein FunctionStructural BiologyMolecular Biology

Improvement of Asparagine Ethylenediamines as Anti-malarial <i>Plasmodium</i>-Selective Proteasome Inhibitors

Wenhu Zhan, Joseph E. Visone, Tierra Ouellette, +16

Journal of Medicinal Chemistry

Design, synthesis and biological evaluation of pyrazol-furan carboxamide analogues as novel Akt kinase inhibitors

Wenhu Zhan, Lei Xu, Xiaowu Dong, +8

European Journal of Medicinal Chemistry

Medicinal ChemistryBiochemistryMedicineNatural SciencesRational Drug Design +9

Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design

Xiaowu Dong, Wenhu Zhan, Mengting Zhao, +15

Journal of Medicinal Chemistry

Discovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors

Wenhu Zhan, Jinxin Che, Lei Xu, +7

European Journal of Medicinal Chemistry

Medicinal ChemistryActive Akt InhibitorsMedicineRational Drug DesignPharmacological Agent +8