Renal claudin-14 expression is not required for regulating Mg²⁺ balance in mice

Abstract

Using transgenic models and in vitro assays, this study examined the effect of Mg 2+ on regulating urinary excretion of Ca 2+ and Mg 2+ via activation of the Ca 2+ -sensing receptor-claudin 14 (CLDN14) pathway. The study suggests that CLDN14 is unlikely to play a significant role in the compensatory response to hypermagnesemia.