Complement Overactivation and Consumption Predicts In-Hospital Mortality in SARS-CoV-2 Infection

Abstract

Increased complement activation is associated with advanced disease severity of COVID-19. Patients with SARS-CoV-2 infection are more likely to die when the disease is accompanied by overactivation and consumption of C3. These results may provide observational evidence and further support to studies on complement inhibitory drugs for the treatment of COVID-19.