An exonuclease protection and CRISPR/Cas12a integrated biosensor for the turn-on detection of transcription factors in cancer cells

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

Janice S. Chen, Enbo Ma, Lucas B. Harrington et al. · Science · 2018 · 4.4K citations

Life Sciences, Genetics, Molecular Biology +13

Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing

Steven Henikoff · Gene · 1984 · 4.2K citations

Life Sciences, Genetics, Molecular Biology +5

Nucleic acid detection with CRISPR-Cas13a/C2c2

Jonathan S. Gootenberg, Omar O. Abudayyeh, Jeong Wook Lee et al. · Science · 2017 · 3.8K citations · Full text

Life Sciences, Biotechnology, Genetics +17

Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6

Jonathan S. Gootenberg, Omar O. Abudayyeh, Max J. Kellner et al. · Science · 2018 · 2.6K citations · Full text

Medicine, Biotechnology, Molecular Biology +17

The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA

Ines Fonfara, Hagen Richter, Majda Bratovič et al. · Nature · 2016 · 1K citations

Life Sciences, Molecular Biology, Molecular Genetics +7