Concepedia

SPARC regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma

Hong-Wei Hua, Haosheng Jiang, Ling Jia, Yiping Jia, Yulan Yao, Yiwen Chen, Feng Jiang, Dongqing Lu, Qing Zhou, Mawei Jiang,

Cancer Biomarkers · 2021 · 18 citations · 15 references

DOI

Abstract

Our findings give a better understanding of ferroptosis and its molecular mechanism in HCC cells that is regulated by SPARC in response to sorafenib.

References

15

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Scott J. Dixon, Kathryn M. Lemberg, Michael R. Lamprecht et al. · Cell · 2012 · 17K citations · Full text

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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

José Pedro Friedmann Angeli, Manuela Schneider, Bettina Proneth et al. · Nature Cell Biology · 2014 · 3.5K citations

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The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells

Christophe Louandre, Ingrid Marcq, Hicham Bouhlal et al. · Cancer Letters · 2014 · 370 citations

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SPARC (Secreted Protein Acidic and Rich in Cysteine) Induces Apoptosis in Ovarian Cancer Cells

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Activating oxidative phosphorylation by a pyruvate dehydrogenase kinase inhibitor overcomes sorafenib resistance of hepatocellular carcinoma

Ying‐Chun Shen, Da‐Liang Ou, Chiun Hsu et al. · British Journal of Cancer · 2012 · 197 citations · Full text