Concepedia

SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury through NF-κB signaling

Huitao Liu, Jingjing Zhang, Xingxing Xu, Sheng Lu, Danlu Yang, Changnan Xie, Mengxian Jia, Wenbin Zhang, Lingting Jin, Xiwu Wang,

Theranostics · 2021 · 160 citations · 71 references

DOIFull text

Open access

Concepts

Abstract

Our results indicate that SARM1-mediated prodegenerative pathway and neuroinflammation promotes the pathological progress of SCI and anti-SARM1 therapeutics are viable and promising approaches for preserving neuronal function after SCI.

References

71

Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety

François Tronche, Christoph Kellendonk, Oliver Kretz et al. · Nature Genetics · 1999 · 1.9K citations

, , +16

Basso Mouse Scale for Locomotion Detects Differences in Recovery after Spinal Cord Injury in Five Common Mouse Strains

D. Michele Basso, Lesley C. Fisher, Aileen J. Anderson et al. · Journal of Neurotrauma · 2006 · 1.8K citations

, , +11

Reactive Astrocytes Protect Tissue and Preserve Function after Spinal Cord Injury

Jill Faulkner, Julia Herrmann, Michael J. Woo et al. · Journal of Neuroscience · 2004 · 1.6K citations · Full text

, , +17

dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

Jeannette M. Osterloh, Jing Yang, Timothy M. Rooney et al. · Science · 2012 · 718 citations · Full text

, , +17

hGFAP‐cre transgenic mice for manipulation of glial and neuronal function in vivo

Lang Zhuo, Martin Theis, Ikuri Álvarez-Maya et al. · genesis · 2001 · 669 citations

, , +14