Loss of Camk2n1 aggravates cardiac remodeling and malignant ventricular arrhythmia after myocardial infarction in mice via NLRP3 inflammasome activation

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

Brydon L. Bennett, Dennis T. Sasaki, Brion W. Murray et al. · Proceedings of the National Academy of Sciences · 2001 · 2.6K citations · Full text

Life Sciences, Immunology, Pharmacology +17

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis

Ting Zhang, Yan Zhang, Mingyao Cui et al. · Nature Medicine · 2016 · 793 citations

Life Sciences, Biochemistry, Cell Biology +14

The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction

Gerardus P. J. van Hout, Lena Bosch, Guilielmus H.J.M. Ellenbroek et al. · European Heart Journal · 2016 · 322 citations · Full text

Medicine, Cardiology, Pharmacology +17

Inflammation and NLRP3 Inflammasome Activation Initiated in Response to Pressure Overload by Ca ²⁺ /Calmodulin-Dependent Protein Kinase II δ Signaling in Cardiomyocytes Are Essential for Adverse Cardiac Remodeling

Takeshi Suetomi, Andrew Willeford, Cameron S. Brand et al. · Circulation · 2018 · 295 citations · Full text

Life Sciences, Cardiology, Physiology +17

Atrial Myocyte NLRP3/CaMKII Nexus Forms a Substrate for Postoperative Atrial Fibrillation

Jordi Heijman, Azinwi Phina Muna, Tina Veleva et al. · Circulation Research · 2020 · 279 citations · Full text

Life Sciences, Cardiology, Cell Biology +17