Concepedia

The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction

Gerardus P. J. van Hout, Lena Bosch, Guilielmus H.J.M. Ellenbroek, Judith J. de Haan, Wouter W. van Solinge, Matthew A. Cooper, Fatih Arslan, Saskia C.A. de Jager, Avril A. B. Robertson, Gerard Pasterkamp,

European Heart Journal · 2016 · 317 citations · 19 references

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Abstract

NLRP3-inflammasome inhibition reduces infarct size and preserves cardiac function in a randomized, blinded translational large animal MI model. Hence, NLRP3-inflammasome inhibition may have therapeutic potential in acute MI patients.

References

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