The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction - Concepedia

Concepedia

Publication | Open Access

The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction

DOI Full Paper Access

317

Citations

19

References

2016

Year

Gerardus P. J. van Hout, Lena Bosch, Guilielmus H.J.M. Ellenbroek, Judith J. de Haan, Wouter W. van Solinge, Matthew A. Cooper, Fatih Arslan, Saskia C.A. de Jager, Avril A. B. Robertson, Gerard Pasterkamp,

European Heart Journal

Abstract

NLRP3-inflammasome inhibition reduces infarct size and preserves cardiac function in a randomized, blinded translational large animal MI model. Hence, NLRP3-inflammasome inhibition may have therapeutic potential in acute MI patients.

References

	Year	Citations
ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation European Heart Journal	2012	6.8K
Genomic responses in mouse models poorly mimic human inflammatory diseases Junhee Seok, H. Shaw Warren, Alex G. Cuenca, Proceedings of the National Academy of Sciences	2013	2.9K
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases Rebecca C. Coll, Avril A. B. Robertson, Jae Jin Chae, Nature Medicine InflammationAnti-inflammatoryAutoimmune DiseaseMedicineNlrp3 Inflammasome	2015	2.7K
ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 European Journal of Heart Failure	2012	2.6K
Inflammasome Activation of Cardiac Fibroblasts Is Essential for Myocardial Ischemia/Reperfusion Injury Masanori Kawaguchi, Masafumi Takahashi, Takeki Hata, Circulation	2011	845
The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse Eleonora Mezzaroma, Stefano Toldo, Daniela Farkas, Proceedings of the National Academy of Sciences	2011	602
The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia–reperfusion injury Øystein Sandanger, Trine Ranheim, Leif Erik Vinge, Cardiovascular Research	2013	501
Anakinra, a Recombinant Human Interleukin-1 Receptor Antagonist, Inhibits Apoptosis in Experimental Acute Myocardial Infarction Antonio Abbate, Fadi N. Salloum, Elena Vecile, Circulation	2008	358
Interleukin-18 and the Risk of Coronary Heart Disease in European Men Stefan Blankenberg, Gérald Luc, Pierre Ducimetière, Circulation	2003	328
A Novel Pharmacologic Inhibitor of the NLRP3 Inflammasome Limits Myocardial Injury After Ischemia–Reperfusion in the Mouse Carlo Marchetti, Jeremy E. Chojnacki, Stefano Toldo, Journal of Cardiovascular Pharmacology	2013	254

Page 1