Theranostics · 2021 · 111 citations · 52 references
MedicineCancer BiologyOncologyCarcinogenesisGene ExpressionMolecular OncologyCancer Cell SignalingCancer MetabolismCarcinogenic MechanismsMetabolic ReprogrammingOncogenic Signaling PathwaysSignal Transduction In CancerGlucose-6-phosphate Dehydrogenase RegulationMalignant ProgressionMicroarray AnalysisMolecular Mechanisms Of CarcinogenesisMyc ActivationNrf2 Pathway ActivationNrf2 Signaling PathwayRedox-sensitive Transcription Factors
Carcinogens trigger c-MYC-directed NRF2 activation. Over-activation of NRF2 promotes malignant progression of HNSCC through reprogramming G6PD- and TKT-mediated nucleotide biosynthesis. Targeting NRF2-directed cellular metabolism is an effective strategy for development of novel treatments for head and neck cancer.
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Comprehensive genomic characterization of head and neck squamous cell carcinomas
ONCOMINE: A Cancer Microarray Database and Integrated Data-Mining Platform
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