Hypoxia and its Modification in Bladder Cancer: Current and Future Perspectives

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations

Life Sciences, Cell Biology, Molecular Biology +17

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

Dorit Shweiki, Ahuva Itin, Dov Soffer et al. · Nature · 1992 · 4.6K citations

Life Sciences, Physiology, Tissue Differentiation +11

The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy

R. H. Thomlinson, L. H. Gray · British Journal of Cancer · 1955 · 2.2K citations · Full text

Medicine, Oncology, Pathology +16

The Concentration of Oxygen Dissolved in Tissues at the Time of Irradiation as a Factor in Radiotherapy

L. H. Gray, Alan D. Conger, M. Ebert et al. · British Journal of Radiology · 1953 · 2.2K citations

Medicine, Cancer Biology, Oncology +14

PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation

Muhammad Zaeem Noman, Giacomo Desantis, Bassam Janji et al. · The Journal of Experimental Medicine · 2014 · 2.1K citations · Full text

Medicine, Immunology, Oncology +16