Concepedia

BRAF V600E mutation as a novel mechanism of acquired resistance to ALK inhibition in ALK-rearranged lung adenocarcinoma

Aixia Sui, Huiling Song, Yitong Li, Litao Guo, K. Wang, Mingming Yuan, Rongrong Chen

Medicine · 2021 · 14 citations · 15 references

DOIFull text

Open access

Abstract

We present a case of ALK-rearranged lung adenocarcinoma with acquired resistance to ALK inhibition, in which the BRAF V600E mutation is a novel resistance mechanism. This provides evidence that BRAF V600E mutation is one mechanism of ALK-TKI resistance.

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