Concepedia

A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage

Xueqing Zou, Gene Ching Chiek Koh, Arjun S. Nanda, Andrea Degasperi, Katie Urgo, Theodoros I. Roumeliotis, Chukwuma A. Agu, Cherif Badja, Sophie Momen, Jamie Young,

Nature Cancer · 2021 · 165 citations · 73 references

Open access

Concepts

Life SciencesGeneticsMolecular BiologyDna RepairDna ReplicationGenome EditingCrispr-cas SystemsDna Damage SignalingDna Repair DefectsError-prone MutagenesisMutation ProcessesMutational SignaturesClustered Regularly Interspaced Short Palindromic Repeats (Crispr) MutagenesisClustered Regularly Interspaced Short Palindromic Repeats (Crispr)-based MutagenesisCrispr-cas9 Genome EditingCrispr-cas9-mediated RepairReplication Errors

References

73

Visualizing Data using t-SNE

Laurens van der Maaten, Geoffrey E. Hinton · Journal of Machine Learning Research · 2008 · 35.7K citations

Computing, Data Science, Visualization +13

BEDTools: a flexible suite of utilities for comparing genomic features

Aaron R. Quinlan, Ira M. Hall · Bioinformatics · 2010 · 30.4K citations · Full text

Life Sciences, Bioinformatics, Genetics +14

An integrated encyclopedia of DNA elements in the human genome

Nature · 2012 · 19.4K citations · Full text

Life Sciences, Genetics, Molecular Genetics +16

Signatures of mutational processes in human cancer

Ludmil B. Alexandrov, Serena Nik‐Zainal, David C. Wedge et al. · Nature · 2013 · 10.1K citations · Full text

Medicine, Cancer Biology, Oncology +14

The repertoire of mutational signatures in human cancer

Mi Ni Huang, Alvin Wei Tian Ng, Arnoud Boot et al. · Nature · 2020 · 3.7K citations · Full text

Life Sciences, Genetics, Oncology +14