Concepedia

Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling

Sameer Nikhar, Ioannis Siokas, Lisa Schlicher, Seungheon Lee, Mads Gyrd‐Hansen, Alexei Degterev, Gregory D. Cuny

European Journal of Medicinal Chemistry · 2021 · 21 citations · 30 references

DOIFull text

Open access

Concepts

References

30

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

Alexei Degterev, Zhihong Huang, Michael Boyce et al. · Nature Chemical Biology · 2005 · 3K citations

, , +17

Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) Detection

Stephen E. Girardin, Ivo G. Boneca, Jérôme Viala et al. · Journal of Biological Chemistry · 2003 · 2.4K citations · Full text

, , +17

Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity

Theonie Anastassiadis, Sean Deacon, Karthik Devarajan et al. · Nature Biotechnology · 2011 · 926 citations · Full text

, , +16

RIP2 Is a Novel NF-κB-activating and Cell Death-inducing Kinase

Justin V. McCarthy, Jian Ni, Vishva M. Dixit · Journal of Biological Chemistry · 1998 · 439 citations · Full text

, , +17

The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

Rune Busk Damgaard, Ueli Nachbur, Monica Yabal et al. · Molecular Cell · 2012 · 384 citations

, , +16