Concepedia

A dysregulated interleukin-18–interferon-γ–CXCL9 axis impacts treatment response to canakinumab in systemic juvenile idiopathic arthritis

Tanja Hinze, Christoph Kessel, Claas Hinze, Julia Seibert, Hermann Gram, Dirk Foell

Lara D. Veeken · 2021 · 33 citations · 31 references

DOI

Abstract

Differential regulation of the IL-18-IFN-γ-CXCL9 axis is observed in patients with SJIA. Higher IL-18: CXCL9 and IFN-γ: CXCL9 ratios at baseline are associated with a better clinical response to canakinumab treatment in SJIA. Future studies are needed to validate these findings and determine their generalizability to patients with recent MAS.

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