Concepedia

The combination of T-2 toxin and acrylamide synergistically induces hepatotoxicity and nephrotoxicity via the activation of oxidative stress and the mitochondrial pathway

Lirui Hou, Shuo Liu, Chong Zhao, Lihong Fan, Hongbo Hu, Shutao Yin

Toxicon · 2020 · 28 citations · 20 references

Concepts

BiochemistryT-2 ToxinLiver PhysiologyMedicineLipid PeroxidationCell DeathMitochondrial PathwayToxicologyHepatotoxicityMetabolomicsExperimental ToxicologyPharmacologyRedox BiologyToxicological MechanismDrug-induced Liver InjuryOxidative Stress

References

20

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

Ting‐Chao Chou, Paul Talalay · Advances in Enzyme Regulation · 1984 · 7.1K citations

Pharmacological Study, Pharmacoepidemiology, Quantitative Analysis +10

Acrylamide is formed in the Maillard reaction

Donald S. Mottram, B.L. Wedzicha, Andrew T. Dodson · Nature · 2002 · 2.2K citations

Engineering, Biochemistry, Organic Chemistry +3

Analysis of acrylamide in cooked foods by liquid chromatography tandem mass spectrometry

Johan Rosén, Karl‐Erik Hellenäs · The Analyst · 2002 · 490 citations

Food Chemistry, Food Forensics, Food Authentication +11

Metabolism and cytotoxic effects of T-2 toxin and its metabolites on human cells in primary culture

Maika Königs, Dennis Mulac, Gerald Schwerdt et al. · Toxicology · 2009 · 100 citations

Cytotoxic Effects, Toxinology, Immunotoxicology +13

Brain oxidative stress after dermal and subcutaneous exposure of T-2 toxin in mice

Manjari Chaudhary, P. Venkata Rao · Food and Chemical Toxicology · 2010 · 94 citations

Brain Oxidative Stress, Allergy, Immunotoxicology +12