Publication | Open Access

Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains

Virus StructureSignal TransductionPh-dependent SwitchSars-cov-2 SpikeCryo-em StructuresReceptor (Biochemistry)Molecular BiologyIntracellular TraffickingViral Structural ProteinMedicineCell BiologyCell SignalingCellular PhysiologyStructural Biology