Aging · 2020 · 17 citations · 1 references
MedicineGeneticsOncologyEpigeneticsMolecular OncologyTranscriptional RegulationCancer EpigeneticsColorectal CancerEpigenetic Alterations In CancerEpigenetic Regulation In CancerNoncoding Rna In CancerTumor Suppressor GenesAntisense RnasEzh2 FunctionOncogenic DysregulationOncogenic TransformationPolycomb Repressive Complex 1Polycomb Repressive Complex 2Zinc Finger DomainsZinc Finger Motifs
rescue assays exhibit that SEMA3F is dispensable for the tumor-promoting effects of FAM83C-AS1 on CRC progression. Our data thus demonstrate that the epigenetic role of FAM83C-AS1 in suppression of SEMA3F expression through stabilization of EZH2 to drive CRC progression, which may be conducive to discovering novel therapeutic targets for the treatment of CRC.
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