E3 ubiquitin ligase UBR5 promotes pancreatic cancer growth and aerobic glycolysis by downregulating FBP1 via destabilization of C/EBPα

Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression

Jingjing Cong, Xianwei Wang, Xiaohu Zheng et al. · Cell Metabolism · 2018 · 375 citations

Life Sciences, Cell Biology, Oncology +14

MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1

Ying Yang, Mari B. Ishak Gabra, Eric A. Hanse et al. · Nature Communications · 2019 · 133 citations · Full text

Life Sciences, Molecular Biology, Oncology +17

Identification of a human HECT family protein with homology to the Drosophila tumor suppressor gene hyperplastic discs

Michelle J. Callaghan, Erica Woollatt, Grant R. Sutherland et al. · Oncogene · 1998 · 119 citations

Life Sciences, Genetics, Molecular Biology +5

E3 Ubiquitin Ligase UBR5 Drives the Growth and Metastasis of Triple-Negative Breast Cancer

Liqiu Liao, Mei Song, Xin Li et al. · Cancer Research · 2017 · 118 citations · Full text

Medicine, Cancer Biology, Oncology +11

EDD, the Human Hyperplastic Discs Protein, Has a Role in Progesterone Receptor Coactivation and Potential Involvement in DNA Damage Response

Michelle J. Henderson, Amanda J. Russell, Samantha L. Hird et al. · Journal of Biological Chemistry · 2002 · 104 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15