Synthesis of novel halogenated triarylpyrazoles as selective COX-2 inhibitors: Anti-inflammatory activity, histopatholgical profile and in-silico studies

Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs

C. A. Winter, Edwin A. Risley, George W. Nuss · Experimental Biology and Medicine · 1962 · 5.7K citations

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Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors:  Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1<i>H</i>-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

Thomas D. Penning, John J. Talley, Stephen R. Bertenshaw et al. · Journal of Medicinal Chemistry · 1997 · 2K citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Synthesis, Anti-Inflammatory Activity, and in Vitro Antitumor Effect of a Novel Class of Cyclooxygenase Inhibitors: 4-(Aryloyl)phenyl Methyl Sulfones

Youssef Harrak, Giovanni Casula, Joan Basset et al. · Journal of Medicinal Chemistry · 2010 · 198 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Inhibitors of cyclooxygenases: mechanisms, selectivity and uses.

R M Botting · PubMed · 2006 · 197 citations

Medicine, Biochemistry, Pharmacology +14

New pyrazole derivatives: Synthesis, anti-inflammatory activity, cycloxygenase inhibition assay and evaluation of mPGES

Ghaneya S. Hassan, Doaa E. Abdel Rahman, Esraa A. Abdelmajeed et al. · European Journal of Medicinal Chemistry · 2019 · 109 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12